Relevance. RF therapy is based on the effect of energy fluctuations of electromagnetic waves in the radio frequency range in involution, tissue of the human body. Today, the study of the effectiveness mikroneedle RF therapy is particularly relevant, rational use of this technology will allow to expand considerably possibilities of aesthetic correction of skin aging changes. Materials and methods. The study included 27 patients aged 30 to 68 years with signs of premature ageing and photodamage to the skin, which was held mikroneedle RF therapy. Evaluation of effectiveness was based on the dermatological status, ultrasonography; visual analogue scale (VAS), photographing patients, quality of life studies and “satisfaction” of patients. For objectification of the results obtained results were compared depending on age: the group of patients under 50 years (n = 16) and patients (n = 11) older than 50 years. Results. The present study showed that application of mikroneedle RF-therapy patients had marked regression of the degree of manifestation of clinical signs of premature ageing of the skin according to an index VAS (qualitative characteristics of the skin and the severity of wrinkles), and according to the ultrasound scan of the skin. The obtained results indicate a significant improvement of quality of life in these patients. The indicator “satisfaction”, which reflects the opinion of the patient based on the comparison of expected and received benefit in comparison with other methods used for similar indications accounted for more than 86% of patients, regardless of age, noted good to very good efficiency and convenience of application mikroneedle RF therapy. Evaluation researcher (doctor) and patients for all items were statistically comparable. Conclusions. Mikroneedle RF therapy is justified is a highly efficient hardware-based method for the correction of involutive skin changes of the face and neck, which allows to recommend this method of treatment for widespread use in clinical practice. Clinically significant anti-aging effect in most patients persists for quite a long time, more than 6 months.

Relevance. The goals of treatment of psoriasis associated with psoriatic arthritis are improving short-and outlying clinical outcomes; improved safety profile of the therapy; reduction of the burden of disease and improving the quality of life of patients; a reduction in the economic burden. In this regard, the development of new methods having efficiency regarding psoriasis smooth skin, and allows to influence the early symptoms of a Dog is very important. In this respect, the scientific rationale for the combined application of narrowband UVB phototherapy and Leflunomide has all the theoretical background. Materials and methods. In the first phase of the study was the screening for the early detection of psoriatic arthritis in patients with psoriasis smooth leather medium-heavy and heavy flow. The study included 186 patients with various clinical forms of psoriasis. All patients answered the questions of the questionnaire PEST when PEST ≥3 points patients were counselled and examined at a neurosurgeon. In the future, have conducted statistical analysis of the obtained data. In the second phase of the study, the patients diagnosed with PSA and psoriasis, smooth skin (n = 58) received combined therapy, including narrowband UVB UV therapy and Leflunomide at a dose of 10 mg/ day orally for 20 days. Results of the study. Need to assess the likelihood of developing PSA in patients with any form of psoriasis. It is particularly important to assess during the first 10 years after the onset of psoriasis. The use of the proven tool for assessment of PSA in the primary care and specialists. PEST - a tool for epidemiological screening of psoriasis. After the examination and consultation of the rheumatologist for the first time the diagnosis of psoriatic arthritis were exhibited in 58 patients, with 56.9%. The results of the study have shown that combined application of narrowband UVB ultraviolet therapy and Leflunomide in patients with different clinical forms of psoriasis and psoriatic artrilom in anteitam and dactylitis is an effective technique (91%), allows to achieve a meaningful clinical effect in relation to skin symptoms and psoriatic arthritis. Developed a combined method greatly improved the quality of life of these patients.

Relevance. One of the most common pathologies of the skin are scars that are in most cases not only cause functional disorders, but also as a cosmetic defect that significantly impairs the quality of life of patients. Despite expanded in the last decade the understanding of the mechanisms of formation of pathological scar tissue and the appearance of new therapeutic options, treatment and prevention of scarring of the skin and at present is a very actual problem. Materials and methods. Under our observation in the outpatient setting were 38 patients with pathological scarring: atrophic scars post-inflammatory origin, and atrophic scars not of inflammatory origin. All patients underwent combined treatment in the form of fractional laser therapy and pharmaphoresis of the preparation of the placental extract. The effectiveness of the therapy was assessed based on the processes of microcirculation. Made a standard entry to the LDF, then conducted a detailed spectral analysis of the frequency components of the LDF signal. Also investigated the morphological structure of the rumen with the help of ultrasonography. The results of the study. The combined method causes a pronounced correction of microcirculatory disorders, as evidenced by improvement in tissue blood flow in a reliably significant reduction in the hypertonicity of arteriolar vessels (ALF/CKO), reduction of stagnation in the venular microcirculation division (AHF/CKO) and strengthening capillary blood flow (ACF/CKO). The application of the combined method improves the epidermal — dermal structures of the skin that is accompanied by a decrease in the thickness of the dermis more than 2 times and an increase in acoustic density of tissues in 2.5 times.

According to the literature, only 10% of the adult population have healthy nails, while up to 50% of the total pathology accounts for non-micotic lesion. Among the etiological factors of occurrence of onychodystrophy, the leading role is played by chronic dermatoses, among which eczema is one of the leading places in prevalence. Material and methods. Under supervision were 25 patients (6 men and 19 women) with onychodystrophies with established diagnosis of chronic eczema outside the exacerbation. To exclude the infectious process in the nail plates, patients underwent 3-fold microscopic and one-time bacteriological (culture) studies. The average age of the patients was 34,2 ± 5,6 years, and the duration of the disease was 3,5 ± 0,7 years. Changes in nail plates were represented by wavy deformations, coilonichia, onychosis, onycholysis, and trachionichia. All patients underwent laser phoresis of the preparation containing biotin, which was applied to the projection area of the nail bed and then subjected to low-intensity infrared radiation (IR NLI) with a wavelength of 0,89 μm. Procedures were carried out from the device “Uzor - A - 2K”, with a frequency of 1500 Hz, with a pulse power of 4–6 W / imp, by contact — labile technique, 1 minute per field, per course — 15 daily procedures. Physiotherapeutic procedures were performed against the background of drug therapy, corresponding to medical standards in this pathology. To assess the severity of the course of the disease and the effectiveness of the therapy, the observed NAPSI (Nail Psoriasis Severity Index) and dermatological index of the patient’s life quality were used in the patients. These indicators were evaluated before treatment and 4 and 6 months after the start of therapy. The evaluation of the microcirculation state was carried out according to laser Doppler fluometry (ALF / CKO AHF / CKO ACF / CKO). Results of the study. Inclusion in the complex treatment of patients with non-infectious onychodystrophies in chronic eczema of biotin laser phophoresis using low-energy laser radiation in the pulsed mode allows to increase the effectiveness of therapy, which is confirmed by the reduction of the NAPSI index by 60,8%.

Relevance. Treatment of patients with the ultimate goal of improving their quality of life is the most important and discussed problem of modern dermatology. The creation of new effective drugs is based on fundamental research of the etiology and pathogenesis of psoriasis, in respect of which, in recent years our understanding has increased considerably. In some cases, PI is the application of biological products have the effect of “escape” effect. When the effect of “escape” at any stage of therapy, it is recommended to consistently pursue the following activities: increasing the dose GIFT according to the scheme used in “primary nonresponders”, reducing the interval between injections, prescription of methotrexate (cyclosporine, UVB 311нм therapy) on the background of continuing therapy GIFT or change one drug to another GSI, with less immunogenicity. Materials and methods. Under our observation there were 38 patients with severe psoriasis (PASI > 10 points) and psoriatic arthritis which had the effect of “escape” on a background of reception of an inhibitor of TNF. Results of the study. The combination of the drug inhibitor of TNF, methotrexate and UVB 311нм all patients were able to stabilize the psoriatic process and achieve positive dynamics. By 6 weeks the number of patients with clinical remission (PASI reduction > 90%) were 34 (89.5 per cent). 4 remained “on duty” plaques while the reduction in PASI was more than 75%. Monitoring throughout the observation period (1 year) with the study of blood (haematopoiesis), blood chemistry (transaminases, triglycerides, bilirubin, alkaline phosphatase) did not reveal any signifi cant negative dynamics. Any adverse events were noted in any clinical case. Conclusions. The combined use of drugs, TNF inhibitors, methotrexate decreasing scheme (15.0 – 10.0 – 5.0 mg/week) and narrowband UVB phototherapy is a justified purpose in patients with frolic effect “escape”. This combination allows to stabilize the process and achieve clinical remission in 100.0% of patients after 6 weeks.

The development of new corrective technologies that increase clinical effectiveness for common somatic diseases, is the main strategy of regenerative medicine. Its distinctive feature is the preventive orientation, which is realized by addressing issues related to improving adaptive capabilities in order to restore and strengthen health, improve professional reliability and longevity based on the predominant use of natural and artificial physical factors, exercise, and factors of traditional therapy [3]. Principles of restorative treatment are applied in many fields of medicine. Search for new, effective technologies of regenerative medicine and integrated their use in urological practice is confirmed by the analysis of statistical data, which demonstrate that currently in the developed world, from 10 million to 400 thousand people suffer from kidney stones disease [6, 13]. Annually 85 thousand diseases urolithiasis, with 62 thousand of them recurrent stones [1]. Mortality from urolithiasis in urological hospitals is 0,7% and in non-specialized branches it reaches 1,5% [9]. Contact lithotripsy, as a major, internationally recognized method of surgical treatment of urolithiasis is complicated by development of acute pyelonephritis in 14,3% of patients, and 0,8% of cases of acute serous inflammation purulent passed in [1, 9]. Renal pelvic reflux that occurs in response to endoscopic manipulation is the initial step in the development of infectious complications at the local level [4]. In response to microbial contamination develops local inflammatory response. The inability of the microorganism to localize an infectious hotbed of interaction macro and a microorganism is outside of the local inflammatory response and, in certain situations, the body is not able to locate the source. Contact with toxins in the blood puts the process at the system level. Despite the attention of urologists to the use of intravenous laser irradiation of blood, information about its use in patients with urolithiasis, in conducting contact lithotripsy insufficient and fragmented. Intravenous laser blood irradiation is an effective means of improving the condition of the body, the treatment of many diseases, effective method of prevention of complications and rehabilitation after surgery. There is evidence of the stimulating effect of laser radiation on cellular and humoral immunity, anti-inflammatory effects, the influence on the processes of lipid peroxidation, detoxifying effects [7]. Our study focuses on the effectiveness of rehabilitation treatment of patients with infected urolithiasis exposed contact lithotripsy with the use of intravenous laser irradiation of blood.

Relevance. The urgency of the problem is determined by the prevalence of chronic oophoritis, with a tendency to chronicity of the inflammatory process, the development of serious pathophysiological and pathomorphological changes in the affected tissues, the involvement in the pathological process of the reproductive system of the body and a significant negative impact on the quality of life of patients. Materials and methods. In clinical conditions were treated 30 patients diagnosed with chronic nonspecific oophoritis. All the patients underwent combined treatment: transvaginal electrophoresis of complex collagenase, a course of 15 procedures carried out 3–4 times a week and impulso magnetic therapy through the day, a course — 10. The results of the study. Combination therapy has a high efficacy against all clinical symptoms, as evidenced by the dynamics of the index ICS HSO, the reduction of which amounted to 72.6%, while the global therapeutic efficiency of the method was 90,0%, quality of life increased by 76.1 per cent.

Abstract. Relevance. The use of phototherapy UVB 311 нм is characterized by high effectiveness, fewer treatments necessary to achieve the effect of reducing the time of exposure by increasing the dose, a longer duration of remission, significantly fewer predictable side effects, the possibility of combination with other types of treatment. The latter became the basis of one of the methods constructed on the effect of radiation potentiation of action of some traditional preparations, for example, calcipotriol. Materials and methods. Under our supervision there were 37 patients aged 6 to 18 years diagnosed with psoriasis with the torpid, resistant to standard therapy for the pathological process. All patients were assigned to a local narrowband UVB ultraviolet therapy and topical drug calcipotriol. The results of the study. The average PASI was thus reducing to of 89,5% (p < 0,05). Global index on average, GSS were thus reducing 93,8% (p < 0,05). Conclusion. 311 нм the use of UVB therapy and topical drug calcipotriol in children with psoriasis is a highly effective method. This method allows to achieve clinical remission and a significant improvement in the vast majority of patients (about 91,8%).

Today the priority direction in therapy of moderately severe and severe forms of psoriasis is phototherapy and, in particular, narrowband UVB has relatively high efficacy and safety, proven in numerous studies. There is evidence of the successful use of this type of phototherapy in combination with cytotoxic drugs. However, studies on the effectiveness of combined use of Leflunomide and UVB 311 нм that sense from the perspective of the treatment of psoriasis smooth skin, and early signs of arthritis psoriaticescom to the present study was not undertaken. Materials and methods. In clinical conditions was carried out examination and treatment of 36 patients with psoriasis and psoriatic arthritis: in 23 (64%) ductility, 13 (36%) — antitime. All patients underwent clinical examination methods that meet the standards for this pathology, and special methods have included the determination of cytokines (IL 1β, IL 2, IL 4, IL 8, IFN-γ, TNF-α). Depending on the conducted treatment, the patients were divided into two comparable on the basic parameters, group: 1 group (main) — 20 patients with psoriasis received narrowband UVB (UVB 311 nm) and Leflunomide 10 mg daily for 20 days. Group 2 (comparison) — 16 patients received UV — b irradiation narrow spectrum with a maximum emission at 311 нм. Results of the study. On average in the first group the decrease in PASI scores was 93.4% (of 1,8 ± 0,2 points) in the second group PASI decreased to 73,7% (7,1 ± 0,6 points). Combination therapy including the use of medium wave narrowband phototherapy and Leflunomide causes the correction of immune imbalance in patients with psoriasis and psoriatic arthritis in the ratio of subpopulations of T-lymphocytes, and most importantly Pro-inflammatory cytokines IL-1β, IL8 and TNF-α, Pro-inflammatory response and immunoregulatory cytokine — IFN-γ have an important pathogenetic role in psoriasis. Combination therapy causes a high therapeutic effect both in terms of the skin and psoriatic arthritis (ductility, intesity), which allows to recommend it for wide application in clinical practice.

Target therapy for various cancers with multi-kinase inhibitors is highly effective. The mechanism of action of this group of drugs is based on inhibition of angiogenesis. However, unfortunately, tropism to the structures of the skin of these preparations gives the development of a toxic reaction in the form of a palmar-plantar syndrome and not only, which does not always make it possible to conduct a full course of antitumor therapy. Determination of adequate correction of skin condition is a necessary component of complex treatment of this category of patients. Materials and methods. We observed 19 patients treated with various drugs from the group of multi-kinase inhibitors. All patients had a toxic reaction to the skin in the form of hand-foot syndrome 2–3 severity. We used the combination of thioctic acid drug in a dose of 600 mg per day for 14 days and the pharmaphoresis of cream containing 0,1% betamethasone valerate for correction HFS. Results. After treatment all patients showed a decrease of severity of clinical symptoms of hand-foot syndrome (erythema, infiltration, desquamation, cracks) and and a decrease in patient complaints (itching, pain, paresthesia), which greatly helps to get a full course of anti-tumor therapy. Conclusions. Patients receiving multi-kinase inhibitor is recommended that a combination for correction of hand-foot syndrome, including oral thioctic acid and farmaforez local corticosteroid cream containing betamethasone valerate.