The aim of the work was to assess the dynamics of the correction of the cognitive status and somatic state in patients with hypertension and risk factors for chronic kidney disease during sanatorium treatment. 200 patients with arterial hypertension were examined, among whom 104 had the risk factors for CKD (group 1). In patients of group 1, compared to patients with hypertension without risk factors for chronic kidney disease (group 2), lower indices of somatic status and cognitive state were found before the start of sanatorium treatment. There was an improvement in indices and a tendency to a decrease in cardiovascular risk after sanatorium treatment in both groups. In the group 1 a decrease in the influence of risk factors for chronic kidney disease was observed.

The article describes the trends in the use of paliperidone dosage forms in the pharmaceutical market of subsidized drugs in Moscow for 2015–2018 in the context of pharmacoeconomic aspects of schizophrenia treatment and theoretical models of pharmacoeconomic research. There is a constant increase in government expenditure on the purchase of injectable forms of paliperidone and there is a steady increase in the number of patients receiving therapy with slow-release drugs. The economic effect of extending the use of slow-release dosage forms of paliperidone by reducing the number of exacerbations of the disease and re-hospitalization to a psychiatric hospital is predicted.

The biopsychosocial factors leading to the development of mental disorders observed in HIV-infected people, their relationship with the severity of the psychoorganic syndrome and affiliation with a specific diagnostic group are considered in this article. It has been found that HIV-associated mental disorders are a complex biopsychosocial phenomenon and are the result from the effect of these factors.

The article presents results of the study on prevalence of early maladaptive schemas in the youth. It included 1853 respondents. It was conducted using the questionnaire «Diagnosis of early maladaptive schemas» (YSQ – S3R, Young Schema Questionnaire Short Form Version 3). According to the data obtained in the course of the study, the highest level of prevalence have schemas «suppression of emotions» and «search for approval». The research clearly showed relevance of the study on maladaptive behavior among young people.

The paper raises the question concerning the relevance of assessing the long-term dynamics of medical prescriptions for different diseases. It is proposed to distinguish and not to equate the cumulative result of therapeutic effects and the result of single or short-term use of therapeutic effects. The study involved 63 patients diagnosed with generalized anxiety disorder (F41.1). The dynamics of subjective indicators were evaluated during 10 weeks in patients with generalized anxiety disorder treated with cognitive behavioral psychotherapy: the level of discomfort associated with the disease and treatment, the level of Sheehan Patient-Rated Anxiety Scale and the average level of severity of the most important symptoms in the patient’s opinion. The frequency of failure to comply with prescriptions was also assessed. The study revealed that from the 8th week of therapy the level of discomfort from the treatment began to exceed the discomfort caused by the disease. It is assumed that there are different types of dynamics of long-term effects of therapeutic prescriptions, the types of such dynamics are proposed basing on the obtained data. And it is concluded that the assessment of this indicator is clinically important in the strategy and tactics of therapy.

The main neurological symptoms of stroke that require rehabilitation are: motor, speech, cognitive impairment and walking disorders. A significant decrease in dependence in activities of daily living and the degree of disability on the Rankin scale was revealed against the background of active rehabilitation measures, which was accompanied by a slight dependence in daily life according to the Barthel scale.

The state of memory, attention and the content of markers of brain tissue damage – S100 protein and neuron-specific enolase – were studied in patients recovering from enteroviral meningitis with pleocytosis in cerebrospinal fluid in the acute period of the disease with less than 100 cells/μL (14 people, main group) and with more than 100 cells/μL (21 people, the comparison group). In the early period of recovery, there was a decrease in memory and attention level in the group of patients with high pleocytosis. The results of the study substantiate the need for medical examination of all patients recovering from enteroviral meningitis.

The article presents the results of surgical and conservative treatment of pituitary apoplexy. The main features of tumors prone to pituitary apoplexy (distribution by sex, age, hormonal activity) are described. The cause of hemorrhage is described. The features of the X-ray picture of pituitary apoplexy are described. In addition, the morphological features of tumors, in the stroma of which hemorrhages occur, have been determined. Also, recommendations are given on the prevention of pituitary adenoma hemorrhage in accordance with the identified causes.

Surgical treatment is the most optimal method for treating drug-resistant epilepsy. Temporal lobe epilepsy is one of the most common forms of drug refractory epileptic syndromes. The surgical results for one third (1/3) of the cases are unfavorable. The presence of an extratemporal epileptic focus in the insular lobe after the resection of temporal lobe in patients with temporal lobe epilepsy is about 20 % of surgical failures. Surgical treatment of pathological processes in the insular lobe has always been considered as challenging, because of its anatomical location and proximity to other important structures. The paper considers a detailed review of modern literature on insular epilepsy surgery.

Effective health management requires the use of assessment tools for its activities. Various algorithms for the performance evaluation of health indicators have been applied in the practice of health management, with the help of which the exception principle of management is implemented. The aim of the work is to develop a simple method for quantitative assessment of the purposefulness of actions for institutions and health authorities to improve health indicators. To achieve this goal, we propose a simple method for calculating the purposefulness of actions to improve health indicators. It is based on calculating a generalized assessment of health indicators for the analyzed years. The proposed method is confirmed by an example of assessing the purposefulness of actions in healthcare in one of the municipalities of the Tula Oblast. The performed calculation showed the lack of efforts to reduce mortality in the region and determined the priorities in this direction. The calculation was made on the basis of data from the regional mortality register and the regional directory of health indicators of the Tula Oblast.