The article substantiates the opinion of Russian and foreign authors that the diagnosis of cardiac diseases and the assessment of cardivascular risk in workers, or those entering a job, is associated with the action of harmful production factors. Among the principal factors leading to the development of work-related cardiac diseases, the main place is occupied by functional overstrain and factors of physical activity. In order to preserve the cardiovascular health of workers, it is necessary to develop Federal clinical guidelines for the diagnosis, treatment and prevention of occupational and work-related lesions of the cardiovascular systems, primarily Federal clinical guidelines on work-related hypertension associated with work (high-risk professions).

The COVID-19 pandemic for healthcare workers is a situation of pronounced emotional stress in connection with professional activities. Healthcare professionals face new challenges in treating COVID-19 and, at the same time, they must also continue to successfully treat non-COVID-19 patients and fulfill personal responsibilities, including caring for their families and themselves. It is imperative to tackle the burnout problem affecting the wide range of healthcare professionals currently battling the COVID-19 pandemic.

Magnesium takes part in metabolic processes and is an indispensable element for the functioning of the nervous, cardiovascular, respiratory systems and the gastrointestinal tract. The article analyzes the role of magnesium in the life support processes of the body, presents to the attention of readers the possibility of diagnosing magnesium deficiency, and substantiates the need for magnesium supplement using mineral complexes in various pathological processes and in order to prevent magnesium deficiency.

Тhe article presents an analysis of current information on the etiology, pathogenesis, and laboratory diagnosis of the human papillomavirus (HPV). HPV is a trigger factor in the pathogenesis of proliferative and inflammatory diseases. HPV-associated cervical cancer is one of the few forms of malignant tumors that can be detected at the precancerous stage or at the earliest stage of cancer: the disease is widespread, has a recognizable preclinical phase, a long period of development, there is a reliable screening test - cytological examination of smears taken from ecto- and endocervix and HPV-testing. Laboratory diagnostics is based on a combination of microscopic (cytological studies) and molecular genetic (PCR) diagnostic methods.

The article presents the data from Russian and foreign literature on the state of humoral and cellular factors of local antimicrobial protection of the mucous membrane of the nasal cavity and paranasal sinuses in the pathogenesis of immune disorders in deviated septum. The role of cellular, humoral factors, and interreceptor interactions of cells of the respiratory, glandular epithelium, phagocytes, lymphocytes in pathological conditions of the nasal mucosa and paranasal sinuses was analyzed. The role of immune mechanisms in the development of pathological reactions in deviated septum is shown. The presented review will expand the understanding of the role of antimicrobial factors in the pathogenesis of immune disorders in deviated septum.

To date, when using the following search terms: «65+”, «elderly person», and «emotional resilience» in titles and abstracts (as well as in combination with medical thematic heading terms), the PUBMED, Scopus and EMBASE databases present 4,500 papers devoted to mental health problems of age 65+ associated with complex epidemic situations; at the same time, there is still not enough research aimed at studying mental health issues during the COVID-19 pandemic. The current situation with the COVID-19 pandemic poses many questions for the psychology community regarding how to get out of an epidemic emergency without losing mental health, how to effectively overcome the problems and further improve social policy in relation to people aged 65+ in the post-pandemic period.

Currently, studying the role of microbiome in the realization of antiviral mechanisms is a relevant issue, especially in the context of the COVID-19 pandemic. It is known that microbiome disrupts the life cycle of viruses in the human organism cells at different stages and stimulates both innate and specific immune response. Such factors as delivery by cesarean section, artificial feeding of a child, early use of antibacterial agents, age-related changes lead to the development of dysbiosis, which increases the body’s susceptibility to viral infections. A positive role of probiotics use is observed in a range of viral infections, including HIV, HPV infection, viral hepatitis, respiratory infections and a number of other diseases.

Endogenous intoxication syndrome is one of the leading syndromes in high urinary system infection activity in children. The study of clinical and laboratory manifestations of endogenous intoxication syndrome with the aim of optimizing its methods of therapy is topical. The examination was conducted in 52 children aged 3–7 years, including 22 children with active forms of pyelonephritis and 30 almost healthy children (control group). Endogenous intoxication syndrome was determined by clinical signs and by the level of leukocyte index of intoxication and medium-sized molecular peptides in blood plasma. Statistical analysis was carried out on the basis of Student’s t-test (p<0.05), the frequency of symptom occurrence (q) in relation to the totality in the group taken for 1 and the coefficients (Q) of the ratio of the comparable indicators in groups. In the control group, the leukocyte intoxication index did not exceed 1.0, the average molecular peptides— 0.24 conditional units. Most patients (q-0.73) had a moderately severe course, expressed symptoms of intoxication, pain abdominal syndrome (q-0.73), dysuria (q-0.73), high temperature (q-0.73). In complex therapy, prebiotic (complex fructoolygosaccharides, inulin and maltodextrin) was prescribed in age dosage for three weeks. Detoxification therapy contributed, first of all, to the positive dynamics of clinical manifestations of the intoxication syndrome. During the first two days, the temperature reaction decreased; on the 4-5th day, the general condition improved, other symptoms of intoxication disappeared; highly reliable (p<0.001) positive changes in the studied indicators were found within 3 weeks. They were characterized by the normalization of the level of leukocyte index of intoxication and medium-sized molecular peptides, which justifies the use of prebiotic products in the complex therapy of urinary system infection in children.