The significance and current state of the veterinary industry in the Russian Federation has been analyzed in the article. The problems and promising directions of development of the veterinary industry have been determined. The tools that contribute to solving the problems facing the analyzed industry have been identified. It was concluded that the veterinary industry should receive new drivers of development in the form of state support, the removal of trade barriers for the introduction of products to target markets, as well as the creation of a system for the promotion and positioning of domestic veterinary products in foreign markets.

When making the Federal state information system “Mercury”, the purpose was to avoid paper carriers when issuing veterinary accompanying documents. In order to obtain the status of “Certified specialist” allows us to independently carry out veterinary activities in the field of electronic veterinary certification and provide veterinary services for the issuance of veterinary accompanying documents. The data on the number of applicants who have passed the certification and were denied the status on the territory of the Volga Federal area have been analyzed in the article.

The purpose of our research was to study the comparative therapeutic effectiveness of the drugs Enroflon and Lexoflon with different methods of administration for the treatment of cows with acute purulent-catarrhal form of endometritis. The experiment included cows of Simmental breed of medium fatness, 4–6 years of age, body weight 456–545 kg with a milk productivity of 4533–5654 kg per lactation. The diagnosis of diseases of the reproductive organs in cows has been made on the basis of an analysis of the data of zootechnical accounting, the results of vaginal, rectal and echographic studies. It has been found by clinical studies and observations that 42,39 % of cows had inflammatory uterine diseases after calving. Subclinical (23,19 %) and acute forms of endometritis (12,86 %) have been dominant. Microbiological studies of the contents of the uterus of cows with acute postpartum purulent-catarrhal endometritis have been shown that the microflora is represented by Streptococcus pyogenes, Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Streptococcus faecium. After a course of therapy of cows with acute purulent-catarrhal endometritis with various drugs, the restoration of sexual cyclicity has been noted in all animals that were administered Enroflon. After the use of the drug Lexoflon the manifestation of sexual cycles has been registered in 88,89 % of cows. After the treatment of cows with the drug Enroflon fertilization occurred in 100 % of the animals of this experimental group with an insemination index of 1,78. The fertilization rate of cows after the use of the drug Lexoflon was 66,67 % with the insemination index of 2,67.

The results of serological studies on brucellosis of cattle and small ruminants in the Central Federal District of the Russian Federation conducted by state veterinary laboratories in 2020 were presented in the article. According to the results of serological studies of 3 197 351 samples of blood serum of cattle positively reacting to brucellosis were detected in 0,006 % of cases in 6 subjects of the district: in the Tambov, Belgorod, Lipetsk, Tula, Bryansk and Kaluga regions. The study of 380 511 samples of blood serum of small ruminants revealed 0,01 % of animals reacting to brucellosis in the Kostroma, Yaroslavl, Ryazan and Voronezh regions. The current epizootic situation of brucellosis of cattle and small ruminants in the subjects of the Central Federal District was close to recovery. For timely detection of animals reacting to brucellosis, continuous monitoring of veterinary safety for this disease should be carried out with the removal of reacting animals from farms, which would completely improve the Central Federal District from brucellosis of animals and eliminate potential and existing risks.

Leptospirosis as a natural focal zooanthroponosis is widespread in the world and continues to be an urgent epizootological, epidemiological and environmental problem to this day. Infection with leptospira of animals of different species remains quite high all over the world. In Russia, leptospirosis is registered in all regions of the Russian Federation in various animal species. The diagnosis of leptospirosis is made comprehensively on the basis of clinical and epizootological, pathoanatomic data and the results of laboratory research (bacteriological and serological investigations). Unfortunately, in the last two decades there has been a situation when laboratory services have almost completely stopped bacteriological diagnostics of human and animal leptospirosis and information on the etiological structure of leptospirosis in the regions is accumulated mainly on the basis of serological studies. The issues of epizootological and epidemiological surveillance of leptospirosis, including the protection of the territories of various countries from the import of new leptospira serovariants, require not only the resumption of bacteriological studies, but also the introduction into practice of veterinary and medical laboratories of new methods for detecting leptospira, including PCR and ELISA. Periodically occurring changes in the nature of epizootic and epidemic processes and the spectrum of the main hosts of leptospira justify the need to monitor leptospirosis infection for the development and improvement of timely and adequate preventive measures.

Under modern conditions of pig breeding an epizootic situation develops when constantly evolving strains of microorganisms with varying virulence are isolated from animals that are not part of vaccines manufactured at biological enterprises. Therefore, polyvalent vaccines against swine colibacteriosis were manufactured from local strains circulating in animals of large pig breeding enterprises. The use of manufactured inactivated vaccines from local Escherichia strains made it possible to reduce the incidence of young pigs compared to the control from 6,0 to 0,5 %, provide newborn piglets with colostral immunity to strains of microorganisms circulating at the enterprise and maintain stable epizootic well-being of pig farms for colibacteriosis.

The purpose of this study was to find and test some means of treatment and specific prevention of edematous disease in piglets. The work has been carried out in agricultural enterprises in the Chuvash Republic. Polyvalent serum against enteropathogenic strains of microorganisms in combination with antimicrobial drugs (Triprim, Ursophenicol) has been tested in farms that were disadvantaged by this disease, which contributed to the improvement of dysfunctional farms for piglet edematous disease. In addition, for the purpose of specific prevention the KoliVak vaccine was tested in combination with a Histalit with a positive result.

The purpose of our work was to study the features of salmonellosis in piglets. According to our observations, the disease in piglets was acute, subacute, and sometimes it was characterized by a chronic course. The severity of the course of this disease in piglets depended on the form of the course of the disease. Especially vivid symptoms and pathoanatomic changes have been noted in the acute course of the disease. In the subacute course the same clinic has been noted as in the acute course, but it has been not as expressed. In the chronic course, in addition to damage to the gastrointestinal tract, damage to the lungs joints has been noted.

The purpose of the work was to identify the advantages of complex treatment over monotherapy in the treatment of open and closed mechanical injuries in animals. In the period from 2017 to 2019, studies were conducted in OOO Krasnodar Hippodrome in the city of Krasnodar, as well as on the territory of private properties of the city of Krasnodar and the Krasnodar Territory on horses of Thoroughbred breed. During the investigation control and experimental groups have been formed (horses with acute aseptic tendovaginitis and infected wounds). In the case of acute aseptic tendovaginitis, nonsteroidal anti-inflammatory drugs (NSAIDs) and APRP therapy have been used as a monotherapy in the groups; APRP therapy together with cauterization has been used as a complex treatment; and NSAIDs together with cauterization have been used in the control group. In groups with the diagnosis of infected wounds, the drug Klemavet, APRP therapy and the ointment Levomekol have been used for monotherapy in the control group; in complex treatment the drug Klemavet has been used together with APRP therapy. As the result of the treatment in groups with closed mechanical injuries with complex therapy using APRP therapy together with cauterization, the rehabilitation period to full sports load (jumping, racing) occurred 4–6 months earlier than in other groups. In this case, there were no relapses of the disease. It has been found when conducting experiments in groups with open mechanical injuries that the use of the drug Klemavet together with APRP therapy has reduced the healing time of wounds compared to other groups by 2–5 days. In both cases complex treatment showed the best result.

The distribution of zoonotic diseases of parasitic origin on the territory of the Russian Federation has been considered. Contamination with echinococci was 33,1 % of animals with parasitosis and 13,1 % of the total number of animals studied, dicroceliosis 66,9 % of animals with parasitosis and 26,5 % of the total number of animalss studied.

It has been found out from the materials of experimental studies have been carried out in 4 main farms for the production of milk in the Saratov region that most often the cows registered retention of the afterbirth (41,98–62,68 %) and endometritis (36,64–53,52 %). Moreover, acute postpartum symptoms have been found in 11,45–25,35 %; chronic in 5,63–9,16; subclinical in 16,03–22,53 %. Of the functional disorders, ovarian hypofunction (10,87–19,72 %), follicular cyst (1,53–6,52), persistent yellow body (3,05–8,69), uterine subinvolution (10,61–24,65 %) have been noted.

The purpose of the research was to evaluate the use of the developed formulations of multifunctional biologically active feed additives for calves during the preweaning period. It has been found that the average daily and absolute gain in the experimental groups in which balsamic poplar kidney extract was used in combination with activated carbon and vegetable protein hydrolysate was higher than in the control group by 11 and 8 %, respectively. Calves have been received the feed additive with activated carbon and extract of balsamic poplar buds outperformed the control group in body girth measurements. In general, based on the results of the conducted experimenct the positive effect of the multifunctional feed additive on the growth and development of calves during the preweaning period has been determined.

The immunosuppressive effect of some mycotoxins is due to activation free radical oxidation, suppression of the activity of T- or B-lymphocytes, inhibition of the synthesis of immunoglobulins.

The dose and frequency of administration of the drug Phytolax and its therapeutic effectiveness have been studied. It has been found that the most effective dose of the drug for the treatment of acute endometritis in cows is 100 ml with an interval of 48 hours no more than 5 times. The therapeutic effectiveness of the drug Phytoflox was 85 %, with a treatment duration of 7,65 days and the percentage of fertilization of cows after the first synchronization was 95 %.

It had been carried out the properties of nanostructured sodium nucleinate in sodium alginate in various ratios using the NTA method and self-organization. The data obtained as a result of the work have been shown that the nanoforms of sodium nucleinate in sodium alginate exhibit great biological activity due to their small geometric shape and can be successfully used for the treatment of young cattle.

The results of research work on the treatment of cow udders before and after milking by means based on probiotic bacteria have been presented in the article. At the dairy complex of OOO “Rodina” in the Yadrinsky area in the Chuvash Republic the udder of cows has been treated with probiotic cleaners before milking PipSkinCleaner and after milking PipCowTeatCleaner manufactured by Chrisal. It has been found at the same time that the use of probiotic drugs has a positive effect on the condition of the mammary gland of cows. Udder treatment leads to the decrease in bacterial contamination and the number of somatic cells in cow’s milk.