One of the reasons for the low efficiency of livestock farms are now widespread diseases of the limbs of cattle mainly in the distal area. Many infectious diseases of cows occur with the defeat of the limbs and therefore of the effective diagnosis depends on the treatment tactics of limb damage.

The purpose of our researches was to study the immunological parameters of healthy and patients with pododermatitis hooves of highly productive cows. The experiments have been carried out in LLC Belonosovskoe in the Etkul’sky district in the Chelyabinsk region. In order to solve this problem, two groups of clinically healthy and patients with pododermatitis cows per five heads in each have been formed. It has been found as a result of the studies that in purulent necrotic diseases of the hooves in cows there is a decrease in the total number of peripheral blood leukocytes due to a decrease in basophils, eosinophils against the background of the shift of the nucleus to the left. There is a decrease in the number of T- and B-lymphocytes by 26,6 and 26,0 %, respectively (Р < 0,05), which indicates the development of immunodefi ciency of cellular immunity and the need for pharmacocorrection of immunobiochemical status of sick cows.

The veterinary and hygienic methods of prevention and treatment of diseases of hooves of cows providing hygiene of housing, feeding and management, functional cutting of hooves by the Dutch flat method on the machine with the manual drive, application of foot bathtubs with solution of copper vitriol and hygienic means of Solka, Espuarol-Gel and Espuarol-Sin have been offered.

In the Republic of Chad as in other African countries anthrax continues to be a serious social and livestock problem. Each year outbreaks are reported in several regions, mainly during the rainy season and less frequently during drought. Long-term experience of veterinary service assures that prevention of this disease in the country does not influence in any way on improvement of an epizootic situation and sources and reservoirs of its causative agent. In order to understand the causes of outbreaks, it is necessary to analyze the impact of prevention on the epizootic situation, to study the ways and mechanisms of transmission, and to use them for control of this disease.

It has been have established by the studies unidirectional changes in humoral factors of nonspecific immunological resistance of saliva and the blood serum of cows and sheep in parasitosis in particular a decrease when helminthiasis and an increase after deworming.

Dicroceliosis of animals is widely spread in many countries of the world, including the Russian Federation, and causes significant economic damage resulting from decrease of the quantity and quality of livestock products and the cost of medical and preventive measures. Along with cattle breeding in Altai, maral breeding is also widespread. Altai Territory is a unique natural and climatic region. According to the geomorphological structure, complex of soil, climatic parametres, relief, the territory of the region is subdivided into 4 natural-climatic zones: steppe, forest-steppe, foothill and salair, according to the level of moisture and moisture saturation: moist, slightly arid, arid and very arid. We carried out a retrospective statistical analysis of the epizootic situation on dicroceliosis of cattle and marals in 60 districts of Altai region and the territories of Barnaul city and the city of Belokurikha for the period 2002–2016. In the process of research, it was revealed that dicroceliosis, as a parasitic system, functioned on the territory of 22 administrative divisions: 21 districts of Altai Territory and the city of Barnaul (which was 35,0 %). The extensiveness of cattle infection with this zoohelminthosis varied from 0,02 to 20,6 %. Extensiveness of dicrocelious invasion of marals in this time period ranged from 51,6 to 84,1 %. Our studies and data analysis show that the causative agent of dicroceliosis is the most common and is regularly detected in areas belonging to the foothill zone (9 areas). There were few cases of the dicroceliosis invasion recorded in: steppe (5 districts of Altai Territory), Salair (4 districts) and forest-steppe (4 districts) zones.

The acaricidal efficacy of domestic and foreign drugs in the fight against psoroptosis of goats in the Caspian region of the Russian Federation was studied. This is-used drugs Alfamen, Aversect-2, Moradok, Dectomax in doses indicated in the instructions for their use. When using the drug Aversect-2 is not achieved full therapeutic effect. Drug Alfamag require re-treatment after 8–10 days to completely get rid of the parasites. Drugs Merdok and Dectomax have 100 % efficiency by a single treatment of goats. Speaking of re-invasion should be noted that after the treatment Alfamag it is detected on 24 days, Aversect-2 on the 20th day of Merdok and Dectomax on the 27-th day. As you can see, the drug Meradok in comparison with the foreign analogue of Dectomax gives similar results, but significantly cheaper in price. The obtained data allow to speak that the most effective prophylactic drug for common scab of goats under conditions of Caspian region of the Russian Federation is Maradok.

The purpose of this work was to study the infl uence of biologically active injection of drugs Nucleopeptide and Catosal on the morphological structure of the liver of rabbits. The objects of research were 30 heads of young silver rabbits at 2 months of age. According to the principle of analogs three groups of 10 heads in each have been formed. Rabbits of the 1st experimental group have been injected with the drug of Nucleopeptide at a dose of 0,5 ml/kg of live weight once for 3 days, a repetition of the course after 14 days. Rabbits of the 2nd experimental group have been injected with a similar dose of the drug Catosal once for 4 days, the course has been repeated at the same time. The control group of rabbits has been kept on a household diet and drugs were not administered to them. The effect of different drugs on the liver has been evaluated by organ weight and histological structure of hepatocytes. The data have been obtained suggest that the weight of the rabbit liver in the 1st experimental group was 115,6±5,4 g, and in the 2nd was 110,5±2,7 g, which by 22,2 and 27,7 % higher than in the control group, respectively. The study of the histological structure has been shown that the volume of the cytoplasm of hepatocytes in the animals of experimental groups has been increased by 1,07 (Р > 0,01) and 1,08 (Р > 0,01) times and was 927,33±45,04 and 939,56±40,43 mkm[sup]3[/sup], vise versus 870,23±34,50 mkm3 in control group. The nuclear-parenchymal ratio in the rabbits of the control group was 9,79 ± 0,81 mkm, in animals of the first and second experimental groups this indicator has increased by 1,32 (P> 0,01) and 2,85 (P> 0,001) times, that confirms the increase in the functional activity of the organ.

A method of prevention of diseases of the postpartum period and the implementation of the biological potential of reproductive qualities of pregnant cows by bio drugs of series Prevention for activation their nonspecific resistance has been provided.

The results of organoleptic, physic and chemical, microbiological studies and determination of the content of toxic elements in fish meat with ligulosis have been presented in the article. The results of the research testify to the deterioration of the chemical composition of fish meat affected by plerocercoids of lanyards.

The effect of the vitamin and enzyme complex and Сaroflavin on the organism of broiler chickens has been studied. It has been found that the studing drug positively influence on liver function, which is manifested by a decrease in the serum of blood to the physiological norm the activity of transamination enzymes and an increase of albumins. After application of the vitamin and enzyme complex the daily average gain weight and natural resistance of the poultry organism increase. The base on the studies have done it is recommended to use to broiler chickens Сaroflavin with feed in a dose 1,0 g/kg of body weight and Vitaferm in the rate 10,0 g/kg of feed throughout the rearing period as a hepatoprotective agent, a stimulator of poultry growth.

Currently in the market of dairy products various types of falsification have been found, which are known to lead to low nutritional and biological value of the product and can be potentially dangerous to human health. Often subjected to adulteration of sour cream, which is in great demand among the consumer. The purpose of our work was to develop histological methods for determination of carrageenan and modified starch in sour cream. As a result of the studies for the first time a histological method has been developed that can accurately identify unacceptable impurities in sour cream: carrageenan and modified starch.