Turmeric (Long Turmeric, Curcuma longa) is a type of plant belonging to the ginger family that grows along the southern and southwestern tropical Asia. Turmeric occupies an important place in the cuisines of Iran, Malaysia, India, China, Polynesia and Thailand, where it is often used as a spice. It is also known that turmeric has been used for centuries in India and China to treat diseases such as dermatological diseases, infections, stress, and depression. Health effects of turmeric are typically concentrated in the orange-yellow lipophilic polyphenolic molecule called "curcumin", which is obtained from the plant’s rhizomes. It is known that curcumin has an antioxidant, anti-inflammatory, antitumor effect and, thanks to these properties, plays an important role in the prevention and treatment of various diseases, in particular cancer, neurological, cardiovascular diseases and diabetes, etc. In addition, its effects are aimed at increasing the adaptive potential of the organism. Curcumin is the most widely studied chemical among curcuminoids. It is a natural phenol responsible for the yellow color of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae.

Role of vitamin D in the formation of pathogenic changes related to factors of innate immunity and cytokine status has been studied in 105 non-working women aged 61.0±1.25 years. Prior to the study, the quality of life has been determined using the SF-36 questionnaire, as well as decrease in total vitamin D content, violation of functional and metabolic status of peripheral blood neutrophil granulocytes, imbalance in subpopulation of lymphocytes, and production of Th1/Th2 cytokines have been revealed. Presence of direct correlation between the qualitative composition and oxygen-dependent metabolism of peripheral blood neutrophil granulocytes, vitamin D content, and cytokine balance has been proved. Vitamin D supplementation in a daily dose of 1000 reduced the severity of immune disorders in the patients, which confirms the need for vitamin D supplementation in the elderly with a vitamin D deficiency confirmed by laboratory tests.

Use of modern certified methods makes it possible to identify the type of allergic reaction. Possibilities of laboratory diagnosis of allergic disorder using immunodiagnostic methods and molecular diagnostic technologies are presented. Examples of using analysis of the results in therapeutic practice, laboratory technologies for in vitro diagnosis of allergy are considered. Features of preanalytical stage of laboratory testing are presented.

The article describes methods of statistical analysis that a physician needs to know in order to conduct medical research. Involvement of internists in training and use of statistical methods of processing and planning will improve their orientation in a variety of existing statistical methods of data processing, as well as will help to understand the importance and relevance of using statistics in medical research in order to create competent, personalized approaches to a patient.

Currently, physical treatment methods, in particular use of photochromotherapy in the treatment of sinusitis, are of interest. Is to investigate the local effect of light in the visible range (450 nm) on the factors of local infection protection of the nasal mucosa. The study involved 50 patients with a diagnosis of acute rhinosinusitis at the age of 27.23±3.29 years. Exposure of the mucous membrane of the nasal cavity was carried out in accordance with the parameters: 450 nm wavelength (monochromatic non-polarized blue light), during 5 minutes for each nostril. Sessions of photochromotherapy were carried out according to the "Sanitary norms and rules for the design and operation of lasers" No. 5804-91. Inclusion of photochromotherapy in the complex of therapeutic measures for patients with acute rhinosinusitis helps to reduce the total number of neutrophils in nasal secretion, normalize their lysosomal activity, NBT-reducing activity, activity and intensity of phagocytosis. Restoration of local immunity factors in nasal mucosa, expressed in normalizing the functional and metabolic status of neutrophil granulocytes of the nasal secretion, can serve as one of the criteria for the effectiveness of treatment using photochromotherapy

Analysis of literature data presented in search engines — Elibrary, PubMed, Cochrane — concerning the risk of developing type I allergic reactions in patients with blood diseases is presented. It is shown that the most common cause of type I allergic reactions is drugs included in the treatment regimens of this category of patients. The article presents statistics on the increase in the number of drug allergies leading to cases of anaphylactic shock in patients with blood diseases. Modern methods for the diagnosis of type I allergic reactions in vivo and in vitro are considered.

Pathogenesis of oxidative stress is based on an increase in the production offree radicals with reduction in potential of antioxidant protection. The article analyzes results ofresearch on the problem of oxidative stress over the past five years, analyzes thepreviously described mechanisms and causes of free radical damage to cells and tissues, and role of such injuries in hypertension. Modern laboratory diagnostic methods for determining antioxidant status are presented. Role of oxidative stress in the pathogenesis of hypertension is considered. Own data of the author obtained during analysis of laboratory and clinical indicators are presented.

It has been determined that a water extract based on herbal mixture No. 1 in combination with antibiotic and antihistamine promotes resolution of purulent-inflammatory process in experimental dermatitis. Water extract based on herbal mixture No. 1 in combination with antibiotic and antihistamine has a pronounced anti-inflammatory and antibacterial effect and can be used in the treatment of allergic dermatitis with opportunistic infection.

The review presents generalized data on respiratory RNA viruses, features of clinical course and diagnostic algorithm. Special attention is paid to the principles oftreatment of diseases caused by RNA viruses.