It is known that in professional activity a person experiences regular physical and psychoemotional overloads (Selye G., 1960). However, to date there is no single point of view about the difference or unity of their clinical manifestations. We made an attempt to conduct a comparative analysis of the effects of chronic stressor effects on the myocardium on the background of professional sports and professional psychoemotional overloads by the example of a group of athletes and locomotive drivers who drive fast moving objects. The material of the study was 55 patients working in the profession of a machinist, with diagnosed chronic stressor cardiomyopathy on the basis of a comprehensive clinical and instrumental examination. These individuals made up group 1. Group 2 consisted of 39 professional athletes engaged in cyclical sports. The average age of the examined in all groups was 32,5±9,5 years. Professional experience was 10±4 years. Clinical, ECG, echocardiography, one-photon emission computed tomography of the heart were performed. The radiopharmaceutical was Myoview (Nycomed, England) — technetium (99 m Tc) tetrafosmin 0,23 mg. Based on the results of the survey, there was no significant difference in the rates of individuals experiencing chronic physical and psycho-emotional overload. Thus, despite the adaptation to the performance of professional duties, individuals with predominantly physical and psychoemotional overstrain have similar clinical and instrumental manifestations of disturbances in metabolic processes.