The paper presents studies on the eff ect of the introduction in ration of probiotics and biologically active additives on the growth and physiological state of fi sh. Positive results were obtained. Thus, the addition in a ration of a probiotic «Subtilis» in the amount of 0,5; 1,5; 3,0 g/kg of feed resulted in an increase in the rate of growth of clarias catfi sh by 6,7–15,5%. This is especially evident during the fi rst stages of growing fi sh. Higher growth rates of catfi sh on the ration with the addition of «Subtilis» are accompanied by better indicators of blood biochemistry and feed payment. Cultivation of Nile tilapia on rations supplemented with 1, 3 and 5% «Metabolit Plus» also contributed to the obtainment of high fi sh-breeding indicators. The best results on the rate of fi sh growth, the effi ciency of feed use were obtained in the variant where 3% «Metabolit Plus» was added to the feed. In fi sh consuming «Metabolit Plus», less deposited in the body of internal fat, which indicates a high plastic metabolism. Along with this, these fi sh have a slow development of reproductive products, which makes it possible to maintain a longer period of growth of muscle tissue. Studies on the use of biologically active supplement «Sangrovit Extra», developed by Phytobiotics Futterzusatzstoff e GmbH (Germany), in feeding of a rainbow trout gave preliminary encouraging results. Trout that was consuming this additive, was more active, consumed food faster, grew more intensively