The high effectiveness of the use of the drug Flyblock® insecticide tag manufactured by AVZ S-P company for the protection of cattle from blood-sucking diptera and licking zoophilic flies has been confirmed.

The supramolecular properties of nanostructured ASD 2-fraction have been investigated and the sizes of nanocapsules ghave been determined by the NTA method in the work for the first time. It has been proposed to use these compounds for the treatment of oncological diseases as well as a wound-healing drug.

The data on studying the properties of nanostructured probiotics on the example of Lactobifadol and Vetom 1,1 have been presented in the work. The size of nanostructured probiotics according to the data have been obtained by the NTA method is 132–176 nm, which allows us to use them for prophylactic and therapeutic purposes.

The purpose of our work was to study the properties of nanostructured lanthanum and cerium nitrates and their promising application as wound healing drugs. The dimensions of nanostructured lanthanum and cerium nitrates have been measured by using Nanosight LM10 multiparameter nanoparticle analyzer manufactured by Nanosight Ltd (Great Britain) in the HS-BF configuration (a highly sensitive Andor Luca video camera, a semiconductor laser with a wavelength of 405 nm and a power of 45 MW). It has been established by the study the presence of fractals in nanostructured lanthanum and cerium nitrates, which indicates the possibility of obtaining a completely different polymer with an almost unchanged composition of the macromolecule. This “new” polymer will have different molecular characteristics and a different suprasegmental structure. They have self-organization. The formation of nanocapsules occurs spontaneously due to non-covalent interactions and this suggests that they are characterized by self-assembly. The size of nanostructured lanthanum and cerium natrate depends on the nature of the shell. Thus, the size of the nanoparticles of lanthanide nitrates in sodium alginate is 467–498 nm, in carrageenan they are also 263–327 nm. According to their characteristics (the size of nanoparticles and biological properties) they may well be promising for use as nanostructured wound healing grugs.

Leptospirosis as a natural focal zooanthroponosis is widespread in the world and continues to be an urgent epizootological, epidemiological and environmental problem to this day. Infection with leptospira of animals of different species remains quite high all over the world. In Russia, leptospirosis is registered in all regions of the Russian Federation in various animal species. The diagnosis of leptospirosis is made comprehensively on the basis of clinical and epizootological, pathoanatomic data and the results of laboratory research (bacteriological and serological investigations). Unfortunately, in the last two decades there has been a situation when laboratory services have almost completely stopped bacteriological diagnostics of human and animal leptospirosis and information on the etiological structure of leptospirosis in the regions is accumulated mainly on the basis of serological studies. The issues of epizootological and epidemiological surveillance of leptospirosis, including the protection of the territories of various countries from the import of new leptospira serovariants, require not only the resumption of bacteriological studies, but also the introduction into practice of veterinary and medical laboratories of new methods for detecting leptospira, including PCR and ELISA. Periodically occurring changes in the nature of epizootic and epidemic processes and the spectrum of the main hosts of leptospira justify the need to monitor leptospirosis infection for the development and improvement of timely and adequate preventive measures.

The distribution of zoonotic diseases of parasitic origin on the territory of the Russian Federation has been considered. Contamination with echinococci was 33,1 % of animals with parasitosis and 13,1 % of the total number of animals studied, dicroceliosis 66,9 % of animals with parasitosis and 26,5 % of the total number of animals studied.

The influence of the probiotic drug Vitabacillin on the livability of newborn calves has been discussed in the article. Two groups of newborn calves have been formed according to the principle of pairs-analogues, taking into account their body weight. Calves of the experimental group on the second day after birth received Vitabacillin in a biotic dose 1 time a day before feeding with colostrum. The control group received a decoction of herbs according to the same scheme (the basic version). The blood has been examined for morphological and biochemical parameters using methods used in veterinary medicine. The effect of the drug on useful and economic indicators was taken into account such as the change in live weight, the average daily gain. The group of calves where Vitabacillin has been used compared with the control group had a statistically significant increase in the content of red blood cells in the peripheral blood by 14,2 %, hemoglobin by 5,5 %, the number of white blood cells and the white blood cell profile reflecting a high level of adaptive processes. They have higher indicators of the total protein content, its fractions, higher serum content (in 66,6 % of calves more than 15 mg/ml) of immune globulins, which provides a favorable prognosis of viability. The alkaline reserve of blood serum was by 4,2 % higher, glucose by 10,2 % higher, as well as the lysozyme and phagocytic activity of blood serum and leukocytes. The influence on the useful and economic indicators has been expressed by the fact that, under equal conditions of feeding and housing, the calves of the experimental group were distinguished by a higher growth energy (the average daily gain was statistically significant in favor of the experimental group by 37,4 %) and at 6 months of age had the live weight higher than the control calves by 3,1 %. The conducted studies allowed us to develop the way to maintain the physiological status of newborn calves.

The best results of treatment of cows with acute postpartum purulent-catarrhal mastitis have been noted in the group of animals where the drug Mastimax was used intramuscularly on the first, second and third days in the amount of 1 syringe dispenser, intramuscularly uberin (25 ml/head/day), penmycin (20,0 ml/head/day), pituitary intramuscularly (5,0 ml/head once). The effectiveness of treatment was 86,0 % of the cured animals. Of these, 66,6 % of cows have been effectually inseminated within 90 days after calving with an insemination index of 1,6.

The problems of industrial veterinary and sanitary control of raw materials and products in meat industry enterprises in the light of modern requirements of science and market economy have been described in the article. The authors discuss ways to improve the effectiveness of state veterinary and sanitary supervision at all sites of production of animal products. Special attention is paid to the training and retraining of veterinary specialists in veterinary and sanitary expertise. It has been noted that it is necessary to increase the level of knowledge and professional experience in inspection work and awareness of responsibility for the results of their activities at any production site. Further professional education is recommended for private entrepreneurs and owners of enterprises engaged in the processing and sale of animal products, on issues of sanitation and hygiene in the production workshops of agricultural enterprises. Practice shows that veterinary medicine doctors who have only good training in all matters of entrance, operational and exit control, who have passed additional professional training under special programs, can effectively carry out veterinary medical examination at various facilities. To do this, it is necessary to develop and approve a unified certification program for veterinary specialists for the whole country, taking into account the peculiarities of servicing various industry enterprises. The development of such a program should be entrusted to experienced employees of branch universities, research institutes and laboratories of veterinary and sanitary expertise. It should reflect the issues of theoretical training and practical activities of veterinary specialists at slaughterhouses, sausage and canning factories, refrigerators and in state laboratories of veterinary and sanitary expertise at markets and fairs. If the problems of State veterinary control at agricultural enterprises are not solved today, then the situation of production hygiene and veterinary and sanitary control of raw materials and finished products will then require significant legislative and legal adjustments, large financial costs and improvement of the norms of the relationship between food producers and their consumers. State veterinary control of raw materials and products is the basis of food security of the population.

The purpose of the work is to realize the reproductive traits of sows and the productivity of piglets by activating the nonspecific resistance of the body with probiotic drugs. For carrying out research work 3 groups of heavy pregnant sows and newborn piglets of the Large White breed have been formed with 10 animals in each group. In order to stimulate the bioresource potential of the animal body, probiotic drugs A2 (the first experimental group) and Immunoflor (the second experimental group) have been used. The use of probiotic drugs A2 and Immunoflor to pregnant sows twice, at the beginning of pregnancy and two weeks before farrowing at the rate of 0,25 kg and 0,08 kg per 1 ton of feed, respectively, ensures normal intrauterine development of fetuses, the health and livability of suckling piglets, increasing the number of viable piglets in the litter by 7,2 and 10,3 % and heavy litter by 11,4 and 3,6 %, and also improves by 9,3 and 10,3 % (P < 0,05) milk production of sows. The administration of probiotic drugs A2 and Immunoflor to piglets for 21 days at the rate of 0,25 kg and 0,005 kg per 1 ton of feed, respectively, helped to reduce the morbidity. During the rearing period the morbidity in the groups was 60,0, 20,0 and 10,0 %, respectively. Recovery in piglets of the experimental groups occurred earlier by 1,4 and 4,0 days than in the control group. By the end of the rearing period the live weight of piglets of the experimental groups was higher by 11,5 and 13,8 kg than in the control group. The administration of probiotic drugs A2 and Immunoflor to pregnant sows and newborn piglets prevents morbidity and contributes to the realization of the reproductive and productive potential of the body.