In the experiment in white rats with gastroduodenal ulcer and bilateral subdiaphragmatic vagotomy, the intake of low-mineralized water for 21days, starting from 30 days after surgery, had a pronounced effect on the secretion of gastrin, glucagon and insulin against the background of optimized metabolism of carbohydrates and lipids. The stimulating effect of mineral water on the motor-evacuation function of the stomach and an increase in the early phase of insulin secretion after oral glucose was detected. It has been proven that activation of the entero-insular axis correlated with a decrease in the hyperglycemic reaction. Conducting a course of mineral water intake 90 days after vagotomy had a smaller impact on the induction of hormones, but at the same time its stimulating effect on the motor-evacuation function of the stomach and activation of the entero-insular axis remained. A hypothesis is proposed on the possibility of using mineral water in the proportion of activation of adaptive reactions of the body in the system of regulation of metabolic reactions after vagotomy against the background of experimental gastroduodenal ulcer.

At present in clinical treatment recommendations of acute cerebrovascular pathology (2016) is presented the new domestic neuroprotectoralbuminous peptide Celleks. The purpose of this research is to increase of neuroprotective action and influence to painful syndrome by the pill of Celleks through the local introduction of magnetophoresis at patients with ischemic stroke. We can see 21patients who are included to the main group, received the pill of Celleks by magnetophoresis in 30 minutes after in-skin introduction. There are 33 persons of the group who received traditional treatment. Complex therapy has been the most effective in the main group which received the therapy by Celleks, where painful syndrome in paretic limbs decreased by 70%. In the group of comparison decrease of the pain by 45% is noted. Patients’ neuropsychological test has showed that application of Celleks bymagnetophoresis are observed reliable decrease as compared with the initial level on the scales of neurotic triad (р < 0,001), the level of depression (р< 0,05), the correction of maladaptation syndrome (р < 0,05) and cognitive disorder (р < 0,01).

Introduction: direct transcutaneous electroneurostimulation (TENS) of the fibular and tibial nerves has been used since 2015 in the treatment of neuropathic syndrome in patients with type 2 diabetes mellitus. However, a comparative analysis has not yet been conducted between the analgesic effect of high-frequency and low-frequency TENS using quantitative, qualitative and projective algic tests. Objective: to conduct a comparative analysis between high-frequency low-amplitude TENS and low-frequency high-amplitude TENS in the treatment of neuropathic pain syndrome in patients with type 2 diabetes mellitus. Materials and methods: 94 patients with pronounced neuropathic pain syndrome 31were examined. They underwent a course of standard medical therapy and besides drug therapy 31 patients underwent high-frequency low-amplitude TENS (100 Hz — 100 µs — painless sensory response) and 32patients — low-frequency high-amplitude TENS (1 Hz — 200 ms — painless motor response). Intensity of pain syndrome was assessed before, after treatment and in the follow-up period within 6 months by visual analogue scale (VAS), McGill Pain Questionnaire (MPQ), ND4 (Douleur Neuropathique en 4 Questions) and Pain Drawing. Results: TENS reliably enhances the analgesic effect of pharmаcotherapy in all applied algic tests: VAS, MPQ, DN4 and Pain Drawing. At the same time, TENS has a prolonged analgesic effect and lasts for the first 6 months of the follow-up period. Directly after treatment, it was revealed that HL TENS has a more pronounced analgesic effect than LH TENS by 35% in VAS, by 45,5% in the evaluative class of MPQ, by 57,6% in the sensory class of MPQ, by 20% in DN4. On the another hand, analgesic effect of LH TENS turned up to be significantly higher than analgesic effect of HL TENS by 51,3% in affective class of MPQ and 22% by Pain Drawing directly after treatment and 57,1% and 16% at the end of the 6th month of the follow-up period. Conclusion: there are significant differences between analgesic effects of HL TENS and LH TENS in different pain Assessments tools. Quantitative parameter and the sensory aspect of pain syndrome regresses more on the background of HL TENS, and the affective aspect of pain syndrome and the area of projection of pain syndrome regresses more on the background of LH TENS.

The results of the evaluation of the effectiveness of complex treatment included magnetic-laser therapy with a matrix emitter of the red spectrum in 72 patients with chronic salpingoophoritis are presented. It has been established that magnetic laser therapy on the background of symptomatic drug therapy promotes effective relief of pain, restores menstrual and secretory functions, improves the parameters of ultrasound examination of the pelvic organs, has a beneficial effect on the psycho-emotional state of patients, thereby increasing the treatment and duration of remission of chronic salpingoophoritis.

Relevance: Due to the increase in the average life expectancy of a person with type 2 diabetes, it becomes more and more, and given that most aesthetic medicine procedures are contraindicated in diabetes, the development of methods for aesthetic correction of involutive changes in this category of patients is a socially significant task. Material and methods: The study was conducted to study the effectiveness of laser technology was carried out in 71 patients with type 2 diabetes. Among them were 62 women (87,3%) and 9 men (12,7%), the average age in the group was 48,6±3,7 years. The patients were divided into 4groups depending on the method of treatment of involutive changes (1A group — non-dime laser + Payler — therapy, 1B group — neodymium laser, 2A — erbium laser + Piler therapy, 2B group — erbium laser). Results: Combined phototherapy to a greater extent than mono-laser therapy contributes to achieving an optimal aesthetic result, which was observed in groups 1A and 2A in 47,1 and 52,6% of patients, while in group 1B and 2B in 17,6 and 22,2% of patients, respectively. The development of side effects in patients with type 2 diabetes depends on the initial level of venous glucose. The exacerbation of a herpetic infection did not depend on the initial glucose level and was noted in patients with frequent exacerbations of herpes infections in history (patients with exacerbations more than 4 times a year were in the group of greatest risk). The use of Payler therapy in patients with diabetes mellitus reduces the risk of infectious complications and the development of predictable side effects by more than 2 times.

We conducted clinical and instrumental examination in 57 patients of 57 women aged 32–45 years and body mass index (BMI — 28–29). All patients had the procedure kriolipoliza (hardware correction of localized fat deposits) podporou on the abdomen, 2 nozzles cool-max, for correction of localized fat is postponed. On the following day, patients complained of hypo-, hyper-, para- or anesthesia, swelling and soreness when touching the skin of the abdomen and pronounced local swelling. When comparing the control and the main group, it was found that the use of injection carboxytherapy significantly improves the quality of life in terms of the dermatological index of quality of life (DIJ). Clinically, edema is reduced, which correlates with a decrease in intra-dermal edema and dermal thickness on the 15th day after cryolipolysis by 73±5%, and three months later — by 97±2% according to ultrasound sensor 22 mhz. Significantly improved initially disturbed basal blood flow in the skin of the abdominal sub-umbilical region, pronounced positive dynamics of changes in the coefficient of variation and microcirculation according to laser Doppler fluorometry, could characterize the restoration of the regulation of tissue blood flow in the area of cryolipolysis. The systemic effect of carboxytherapy on clinical and biochemical parameters of blood was noted. Injection carboxytherapy is an effective factor of relief of complications after cryolipolysis.

Task of this review is synthesis of the data on a current state of cryotherapy published in scientific literature. Mechanisms of action of low temperatures on a human body are stated, clinical effects of cryotherapy are presented. Results of clinical supervision at application of cryomassage and a modern naprvleniye of cryoimpact on the patient — local air cryotherapy at treatment of various diseases at adults and children are given in the review. The special place in the presented material is allocated for a statement of new technologies of cryotherapy in pediatrics.

Objective: to study the mechanisms of the influence of ozone rectal insufflations on some pathogenetic reactions of arterial hypertension and metabolic syndrome. Studies were conducted on 30 patients with arterial hypertension associated with metabolic syndrome, which were randomly divided into 2 groups, one of which received rectal ozone insufflations, and the second (control) rectal air insufflations. The concentration of glucose, total cholesterol, high density lipoproteins, triglycerides, as well as the content of insulin, cortisol and aldosterone were determined by immunochemical method in the blood of patients on a biochemical analyzer. It has been established that a single ozone therapy procedure has a hypotensive effect, inhibits the secretion of insulin and aldosterone, while the insulin resistance index HOMA significantly decreases and the balance between pro- and antioxidant reactions is restored. The response of patients to a single action of ozone is stressful in nature, as evidenced by increased production of cortisol and activation of prooxidant reactions, although this has not been clinically shown. A hypothesis is proposed that short-term stress activates pro-oxidant reactions, decreases the viscosity of cell membranes and thereby contributes to a reduction in the effects of insulin resistance. The results indicate a high hypotensive and metabolic potential of rectal ozone insufflations, which makes it possible to consider this rather simple method from the arsenal of restorative medicine as promising in the complex therapy of arterial hypertension associated with the metabolic syndrome.

The article contains the results of research on the effectiveness of high-tech care in the prevention and treatment of meteopathic reactions in cardiac patients at the stage of early rehabilitation in the sanatorium-resort conditions of Gelendzhik. The aim is to study the effectiveness of high-tech medical care in the prevention and treatment of meteopathic reactions in cardiac patients at the stage of early rehabilitation. Results. Detailed study of the climatic characteristics of the area during the study period, an analysis of meteopatic reactions in patients who underwent heart surgery — shunting and stenting, analysis of clinical studies, diaries of self-observation. The comparative characteristics of meteorological reactions in cardiac patients according to the seasons of the year are given. Based on the analysis, it was found that meteopathic reactions can be regarded as symptoms of the existing underlying disease at the stage of compensation of adaptation mechanisms or initial disturbances of these mechanisms. The comparative characteristics of meteorological reactions in cardiac patients according to the seasons of the year are given. Based on the analysis, it was found that meteopathic reactions can be regarded as symptoms of the existing underlying disease at the stage of compensation of adaptation mechanisms or initial disturbances of these mechanisms. The conclusion. High-tech heart surgery — bypass and stenting — are both preventive, curative, and also differential-diagnostic method in the prevention and treatment of meteopathic reactions in patients with circulatory system diseases.

Neurological complications exacerbate the course and prognosis of insulin-independent diabetes mellitus, therefore, the development of complex methods of influence on various pathological disease reactions is required. Mesodiencephalic modulation has a proven clinical effect in the treatment of diabetic polyneuropathy, but its mechanisms of action are not well understood. It has been established that with a single application of this physiotherapeutic procedure, a mild stress effect is first noted — an increase in glycemia and cortisol secretion, which is then replaced by a decrease in the glucose level in the blood and insulin resistance index. Lipid metabolism was almost unchanged. 60 minutes after exposure, a decrease in neurological deficit and activation of antinociceptive factors, serotonin and β-endorphin, amid regression of pain syndrome are observed. The hypothesis of the systemic nature of the effects of mesodiencephalic modulation is considered, which ensures its therapeutic effect.

The article reviews modern literature and scientific articles on the problem of chronic endometritis as one of the main causes of miscarriage and modern physiotherapy methods of treatment and rehabilitation.

Different types of fillers used in cosmetology practice may have a different safety profile. The article deals with the main types of complications and the possibilities of their prevention using ultrasound of the skin and soft tissues of the face. On the presented clinical examples, the description of the ultrasound picture is examined in detail, which facilitates the understanding of the basic diagnostic principles of this research method. Also provides data on the correction of these complications.

The article presents the results of the use of general magnetic therapy in the early postoperative period in patients with uterine adenomyosis in the early postoperative period after FUZ-ablation. The study involved 96 women who were divided into 2 groups: the main group — 48 patients who, in the early postoperative period after FUS-ablation, on the background of standard treatment, received a course of general magnetic therapy consisting of 10daily procedures and a control group — 48 patients received only standard treatment, including symmetrical and analgesic therapy. In the initial state, the patients had a violation of the hemostasis system, which was manifested in a significant increase in all studied parameters: the platelet platelet platelet activity index 1,27 times (р < 0,05); activated partial thrombin time — 1,23 times (р < 0,05), fibrinogen A — 1,57 times (р < 0,01), blood clotting time — 1,21 times (р < 0,05) and the accumulation of fibrin degradation products, as well as a moderate increase in FSH — by 1,38 times (р < 0,05) against the background of a decreased by 1,62 times (р < 0.05) estradiol content (for 5–7days of the menstrual cycle) adecrease in progesterone by 4,3 times (р < 0,05) and a moderate increase in LH by 1.39 times (р < 0,05) in blood serum and against the background of an increase in 1,8 times the level of cortisol (р < 0,05) for 20–22 days of the cycle. After the course of treatment, it was found that the use of general magnetic therapy in patients in the early postoperative period after FUS-ablation for adenomyosis contributes to the normalization of hemostasis system indicators and the elimination of hormonal imbalance.