Enzyme-linked immunosorbent assay (ELISA) is a method for detecting antigens and antibodies in biological fluids. The method is characterized by high accuracy and sensitivity, and allows determining not only the qualitative, but also the quantitative composition of antigens and antibodies in the body. In medicine, enzyme immunoassay is used to detect diseases that are provoked by microorganisms of various classes, from viruses to parasites, as well as to diagnose autoimmune diseases.

The purpose of this study is to determine the prognostic value of factor signs for the effectiveness of anticoagulant and antiplatelet therapy in patients with severe COVID-19. Materials and methods: The frequency of cerebrovascular complications in severe COVID-19, the background of comorbid conditions of the cardiovascular continuum, the levels of hemostasis and inflammation markers were studied. Results: With a sum of prognostic indicators equal to 2.7, the probability of developing cerebrovascular complications is less than 1%. With a prognostic indicator equal to 34.41, the probability of developing cerebrovascular complications approaches 100%. Conclusions: The proposed prognostic scale, which takes into account the pathogenetic features of the relationship between markers of inflammation and coagulation, should be used in the treatment of patients with severe COVID-19 to identify the cohort of patients at high risk of developing cerebrovascular complications by summing the prognostic indicators depending on the presence of comorbid conditions of the cardiovascular continuum and the levels of markers of inflammation and thrombosis.

Mineral waters make it possible not only to influence significantly the processes of normal life, replenishing the body with the necessary microelements and biologically active substances that are produced by certain microbes living in water, and to maintain the necessary acid-base balance and water balance in the body, but, most importantly, they allow successfully treating many diseases and increasing the body's defenses. Mineral waters contain more than 50 different chemical elements in the form of salts: bicarbonates, sulfate chlorides, metals, and microelements (potassium, sodium, calcium, magnesium, iron, copper, zinc, molybdenum, cobalt, fluorine, iodine, bromine).

Fungus balls of the paranasal sinuses are one of the forms of non-invasive mycosis. Typical location of fungus balls of the paranasal sinuses is maxillary, sphenoid, ethmoid, and frontal sinuses. The article describes a case of a rare localization of the fungus ball in the ethmoid bulla.

The article analyzes the importance of conducting diagnostic studies in the practice of an ENT doctor. The purpose of the study: to analyze the effectiveness of modern algorithms for allergy diagnostics using molecular genetic methods and their importance for an ENT doctor.

Sleep-related breathing disorders in children are usually caused by adenotonsillar hypertrophy and associated with many related disorders: pulmonary hypertension, developmental delay, sleepwalking, attention deficit hyperactivity disorder, obstructive sleep apnea, and enuresis. Numerous studies indicate the correlation of the above syndromes. Surgical removal of airway obstruction (adenotonsillectomy) in most cases leads to complete resolution or significant improvement of comorbid disorders. A comprehensive interdisciplinary approach to the examination of this category of patients and their treatment with the participation of pediatricians, psycho-neurologists, and ENT specialists is required.

Today's children and adolescents are immersed in both traditional and new forms of digital media. Research on traditional media, such as television, has identified health concerns and negative outcomes that correlate with the duration and content of viewing. Over the past decade, the use of digital media, including interactive and social media, has grown, and research evidence suggests that these novel media offer both benefits and risks to the health of children and teenagers. Evidence-based benefits identified from the use of digital and social media include early learning, exposure to new ideas and knowledge, increased opportunities for social contact and support, and new opportunities to access health promotion messages and information. Risks of such media include negative health effects on sleep, attention, and learning; a higher incidence of obesity and depression; exposure to inaccurate, inappropriate, or unsafe content and contacts; and compromised privacy and confidentiality.