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УДК: 616.89 DOI:10.33920/med-01-2108-01

A comparative analysis of the intellectual–mental disorders in patients with brain gliomas and meningiomas after surgical treatment

Kurnukhina Maria Yuryevna senior laboratory assistant, post-graduate student of the Department of Neurosurgery of the I.P. Pavlov PSPbSMU, 197022, Russian Federation, St.-Petersburg, Lva Tolstogo St., 6–8, http://orcid.org/0000-0002-0254-4066, al-mary@mail.ru, +7-921-383-19-17
Mukhitova Yulianna Vladimirovna Ph. D., Associate Professor of the Department of General and Clinical Psychology of the Pavlov PSPbSMU, 197022, Russian Federation, St.-Petersburg, Lva Tolstogo St., 6–8, Che88@mail.ru, https://orcid.org/0000-0003-4172-6257, +7-921-570-13-43
Vladislav Yuryevich Cherebillo MD, Professor, Head of the Department of Neurosurgery of the I.P. Pavlov PSPbSMU (197022, Russian Federation, St.-Petersburg, Lva Tolstogo St., 6–8), Professor of the V.A. NMITS Almazova «of the Ministry of Health of the Russian Federation, FGBVOU VO «Military Medical Academy named after S.M. Kirov» of the Ministry of Defense of the Russian Federation, http://orcid.org/0000-0001-6803-9954, cherebillo@mail.ru, +7-921-903-63-87
Isayeva Elena Rudolfovna Doctor of Medical Sciences, Professor, Head of the Department of General and Clinical Psychology of the Pavlov PSPbSMU, 197022, Russian Federation, St.-Petersburg, Lva Tolstogo St., 6–8, isajeva@yandex.ru, https://orcid.org/0000-0002-2969-7847, +7-921-956-33-41

Objective. A analysis of the intellectual-mental disorders in patients with gliomas and meningiomas after surgical treatment Material and methods. We performed study of 61 patients with brain glioma and meningioma. The diagnosis of the studied patients was based on clinical and laboratory data, data of radiation and instrumental methods of research. The analysis of patientsquality of life was carried out in the preoperative and early, late postoperative periods. The patient age ranged from 25 to 65 years; the median age was 56,5 year. We used the intelligence tests (Amthauer test (for persons under 60 years), Raven test); memory tests (10 word memorization test, Wechsler memory scale). Results. Regression of mnestic disorders after surgery was found in both groups. Three months after surgery — mnestic disorders were observed in 96.7 % of subjects with glioma, and in 64.5 % — of meningioma. After 3–6 months, the number of patients with high intelligence in both groups increased (from 32.3 % to 45.2 % — in patients with glioma and from 30 % to 40 % among meningioma patients). Conclusion. On examination of intelligence and memory before and resection brain glioma and meningioma, it was found that surgical intervention leads to regression of intellectual and memory impairments.

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Currently, the incidence of various primary neoplasms of the brain ranges from 7.42 to 13.9 per 100 thousand of the population and, according to several foreign studies, tends to further increase. [1]

Neuroepithelial tumours account for up to 58 % of all primary brain formations in adults. Brain gliomas are the most common neuroepithelial tumours. [2–5]

The second most common among primary intracranial tumours in adults is occupied by meningiomas of the brain. According to different authors, their occurrence varies from 18 to 34 %. [6–7]

In recent years, the results of the surgical intervention have significantly improved, the frequency of intraoperative complications, relapses, mortality has decreased, due to an increase in the arsenal of therapeutic effects on various neoplasms. [8]

Currently, the general principle in the treatment of patients with various brain tumours is oncotomy. [9]

Cerebral tumours are traditionally considered a disease with a high probability of death and disability of patients.

Defects of higher cortical functions, changes in the mental sphere and defects of intellectual and mnestic function are among the disabling clinical manifestations of gliomas and meningiomas of the brain.

The purpose of this study is to analyze changes in intellectual and mnestic disorders in patients with gliomas and meningiomas of the brain before and after surgical treatment.

Materials and Methods We conducted a study of patients hospitalized from September 2017 to October 2018, who underwent surgical intervention for glioma and meningioma of the brain at the Neurosurgical Department.

61 patients were studied (gender: 39 women and 22 men), 30 patients had a histologically confirmed diagnosis of cerebral glioma, 31 — cerebral meningioma. The age of the subjects varied from 25 to 65 years, the average age: 53.1 ± 9.8 years, the median: 57 (46/61) years. The diagnosis in the studied groups of patients was based on clinical and laboratory data, data from radiation and instrumental research methods.

Для Цитирования:
Kurnukhina Maria Yuryevna, Mukhitova Yulianna Vladimirovna, Vladislav Yuryevich Cherebillo, Isayeva Elena Rudolfovna, A comparative analysis of the intellectual–mental disorders in patients with brain gliomas and meningiomas after surgical treatment. Вестник неврологии, психиатрии и нейрохирургии. 2021;8.
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