The article presents data on introduction of monitoring of acute poisoning of chemical etiology of population in Rostov-on-Don, organization of this activity by the branch of the Federal State-Funded Healthcare Institution "Hygienic and Epidemiological Center in Rostov Region" in Rostov-on-Don, trend for 2008-2016 years.

The problem of acute alcoholic hepatitis remains relevant both in Russia and abroad in view of its widespread occurrence, high risk of complications development and death of them. To date practicing physicians are experiencing certain difficulties in the formation of approaches to the diagnosis and treatment of complications of acute alcoholic hepatitis (OAH). The review of the literature presents modern views on the possibilities of diagnosis and therapy of alcoholic liver disease (ALD). Data on genetic markers associated with the development of ALD and alcohol addiction are given. Action mechanism of modern drugs in the context of the disease inquestion are discussed in detail. The indications of some drugs for alcoholic hepatitis are substantiated. Therapeutic approaches to diagnostics and treatment of alcoholic hepatitis are considered.

Algorithms for actions of personnel of medical organization for observing the cold chain in emergency situations associated with power outages and supercooling and freezing of IMP are developed and presented, based on the results of the analysis of requirements of current regulatory and legal acts and practices of healthcare organizations on the transportation and storage of immunobiological medicinal products (IMP).

The analysis of the outbreak of bacterial food poisoning caused by Proteus mirabilis in the village of Pravda, Mogol settlement, Bazar-Kurgan district, Jalal-Abad region of the Kyrgyz Republic is presented. It was determined that the disease was of single-step type and was associated with eating the same product ("Olivier" salad) at the same time (during the wedding event). The wide-scale of the disease was promoted by the violation of sanitary and hygienic conditions for preparation and storage of salad, which became the main factor in the transmission of infection. The outbreak concerned people of all age groups and social strata living in different settlements. The majority of victims (63.8%) appealed to for medical aid within first 24 hours. Severe forms of the disease prevailed among hospital admitted patients (75.9%), the duration of treatment depended on the severity of disease. Proteus mirabilis, found in 47.2% of cases, was main etiological agent that caused the disease. Negative bacteriological studies of other patients can be associated with insufficient quality of laboratory diagnostics, sampling of materials after the initiation of antibacterial treatment, and also with the presence of viral pathogens, studies for which presence are not carried out in the conditions of district centers of the Kyrgyz Republic.

The results of a study on the quality of water supply sources on sanitary and chemical indicators in the villages of the Saratov region are presented. It is determined that the quality of water sources of drinking water supply in a number of rural settlements of the Saratov Zavolzhye (Transvolga region) does not meet the requirements of sanitary regulations for following indicators: turbidity, color, oxidizability, hardness and manganese content. The degree of nonconformity to hygienic standards is most significant in the spring.

Assessment results of marking of children's toys by method of photorecording of samples, sold at various trading platforms of St. Petersburg city, are presented, followed by marking analysis and entry of results in the record protocol of accounting characteristics. The choice of sample toys for analysis was made in a random order. The received data were put in a database with the subsequent statistical manipulation. 140 samples of toys were analyzed, including 52 samples from large chain stores, 55 from small retail outlets, 33 from system of online shopping in China. It was found that 61% of all samples did not comply with the requirements of sanitary legislation in terms of marking, such as the absence of manufacture date, absence of a unified mark of product circulation on the market of the Member States of the Customs Union, absence of a toy life cycle or working life and others. Most of violations of marking per 100 samples was detected in samples with no information on the country of the manufacturer, samples produced in China are in the second place, samples produced in Russia, Belarus and other countries are on the third, fourth and fifth places respectively. Depending on the place of sales, the maximum number of marking violations per 100 samples of children's toys was found in samples sold in the system of online shopping in China, samples sold in small retail outlets are in the second place, the smallest number of violations detected in samples sold in large chain stores.

Stages of development of state medicine in the Russian state during the ХVI-ХIХ centuries and the implementation of preventive and sanitary and anti-epidemic measures to protect public health are outlined.

Historical review of the formation of the sanitary service of Russia for the period from 1871 to 1922 is presented.