Pseudorabies (Aujeszky’s disease) virus Suid herpesvirus 1 (SuHV-1) belongs to the species of viruses of the genus Varicellovirus of the subfamily Alphaherpesvirinae within the family Herpesviridae, and is capable of causing damage to the central nervous system and other organs (including the respiratory tract) in almost all mammals, except humans and tailless monkeys. A technique aimed at determining the titer of the virus in a cell culture is necessary for quality control at various stages of biotechnological production, for instance, at the end of the stage of viral purification of biotechnological products/by-products or when conducting quality control tests for medicines.

Mortality and hospital lethality from stroke in a multidisciplinary hospital rank first. One of the main reasons for an unfavorable outcome, especially in elderly patients, is the addition of pneumonia caused by a nosocomial infection. The study was conducted at the Regional Vascular Center of the St. Joasaph Belgorod Regional Clinical Hospital.

Today, the problem of drug-drug interactions is relevant in clinical practice, since such interactions often lead to an undesirable pharmacological effect. This problem is encountered in many areas of medicine, including cardiology practice.

Chest pain is one of the disease symptoms most often encountered in general medical practice. Despite the annual increase in the number of patients visiting various medical and diagnostic institutions with a wide variety of chest pain, many practicing doctors do not fully identify the whole variety of causes that provoke chest pain, and the methods and tactics for examining this group of patients have not yet been fully developed. That is why errors made by doctors in the differential diagnosis of chest pain are not uncommon, especially at the preliminary stage of examining patients. Meanwhile, it is known that chest pain syndrome can be associated not only with heart disease, but also with diseases of the digestive organs, respiratory system, mediastinum, and musculoskeletal system. In particular, gastroesophageal reflux disease (GERD) and esophageal motility dysfunction are currently given great importance in the genesis of chest pain.

Alcohol consumption is one of the four most common preventable and modifiable causes of major noncommunicable diseases, with complex dose-dependent effects on the cardiovascular system. The Global Burden of Disease (GBD) Alcohol Collaborators’ Study has found that alcohol is the seventh leading risk factor for both deaths and disability-adjusted life years (DALYs), accounting for 2.2% [95% UI 1.5–3.0] of age-standardized mortality rate in women and 6.8% (5.8–8.0) of age-standardized mortality rate in men. There are difficulties in interpreting the data regarding the effects of alcohol consumption on health. Observational and prospective studies consistently show a lower risk of cardiovascular and all-cause mortality in people with low alcohol consumption compared with nondrinkers (J-curve).

Despite significant advances in medicine, cardiovascular diseases remain the leading cause of morbidity and mortality. Currently, the prevalence of atherosclerosis and its complications such as ischemic (coronary) heart disease and stroke is increasing in most countries. In addition to acute complications, atherosclerotic lesions of the carotid arteries are characterized by the development of cognitive impairment and dementia. A surgical method for preventing ischemic cerebral infarction in atherosclerosis of the carotid arteries is carotid endarterectomy. Some studies indicate that in the postoperative period, in addition to carotid artery atherosclerosis, atherosclerosis of small cerebral vessels, gender, diabetes mellitus, hypercholesterolemia, previous ischemic stroke, and body mass index correlate with a decrease in cognitive abilities.

The main cause of postoperative inflammatory reactions are pathogenic microorganisms. Therefore, antimicrobial therapy is necessary to prevent infectious complications after ophthalmic surgery treatment, including intravitreal injections. To effectively select an antibacterial drug, it is necessary to know the exact species composition of the conjunctival microbiota of premature infants. However, information about their natural microbiota is very limited.

The work is devoted to assessing the possibility of using a large open-source language model running on a local computer as an additional source of information for a doctor in matters of diagnosis and treatment of diseases. Preloaded texts of clinical guidelines (arterial hypertension and diabetes mellitus) were used. Testing showed acceptable accuracy of neural network responses. It is assumed that the created support system for medical decision-making can be used by medical workers in rural areas without access to the Internet.

The purpose of the work is to study the features of professional burnout in physicians of GP and surgical profiles depending on specialization. The study included: group 1 – gastroenterologists (n=52); group 2 – cardiologists (n=58); group 3 – oncologists of the GP profile (n=48); group 4 – general surgeons (n=71); group 5 – cardiovascular surgeons (n=30); group 6 – surgical oncologists (n=65); group 7 – control: workers in engineering, technical, and economic fields, not related to medical organizations (healthy) (n=75). The assessment of the professional burnout was carried out using the Maslach Burnout Inventory developed by C. Maslach and S.E. Jackson and adapted by N.E. Vodopyanova. It has been established that the professional activity of physicians of GP and surgical profiles is associated with the impact of chronic occupational stress, leading to the development of professional burnout.

Introduction. Medical workers, including general practitioners, are one of the most vulnerable categories among helping professions in terms of the formation of disorders of the psycho-emotional sphere, an increase in the levels of occupational stress and professional burnout, an increased anxiety level, and a decrease in the quality of life. Purpose. Establishing the characteristics of the state of the psycho-emotional sphere among doctors of therapeutic specialties (oncologists of the therapeutic profile (outpatient oncologists), pulmonologists, occupational pathologists, who, along with medical work, deal with issues of examination of the relationship of the disease with the profession and examination of professional capability). Material and methods. The study was performed at the Department of Occupational Diseases and Clinical Pharmacology named after honored scientist of the Russian Federation professor V.V. Kosarev, FSBEI HE Samara State Medical University of the Ministry of Health of the Russian Federation, and the regional center for occupational pathology SBHI SR Samara City Hospital No. 5. The following groups of doctors were examined: group 1 included oncologists of the therapeutic profile (outpatient oncologists) of the outpatient departments of the state budgetary healthcare institutions of the Samara Region (n=30); group 2 consisted of pulmonologists of the clinics of the FSBEI HE Samara State Medical University of the Ministry of Health of the Russian Federation, SBHI SR Samara Regional Clinical Hospital named after V.D. Seredavin, SBHI SR Samara City Hospital No. 5, and outpatient departments of the State Budgetary Healthcare Institutions of the Samara Region (n=30); group 3 included occupational pathologists of the occupational pathology department of the Regional Center for Occupational Pathology of the SBHI SR Samara City Hospital No. 5 and outpatient departments of the state budgetary healthcare institutions of the Samara Region (n=42); group 4 was the control group that included workers in engineering, technical, and economic specialties whose activity is not related to work in medical organizations (n=190). The assessment of the professional burnout was carried out using the Maslach Burnout Inventory developed by American psychologists C. Maslach and S.E. Jackson in adaptation by N.E. Vodopyanova and E.S. Starchenkova, as well as by means of the questionnaire by V.V. Boyko. The processing of the obtained data was carried out by means of the Statistica package from StatSoft (USA). Results. It has been established that the work of physicians of GP specialties is associated with the impact of occupational stress and an increase in the level of professional burnout. Limitations of the study. The study has regional (Samara Region) and professional (in terms of detailing working conditions in the studied comparison groups) limitations. Conclusions. The work of physicians of GP profile is associated with an increase in the levels of occupational stress and professional burnout. At the same time, psychological changes are most pronounced in oncologists of the therapeutic profile (outpatient oncologists), as well as occupational pathologists. It is necessary to continue research into the emotional state of medical personnel in order to conduct timely preventive treatment to maintain the health of medical workers.

The authors conducted a retrospective analysis of the medical records of a patient who took warfarin for prosthetic mitral and aortic valves. The goal was to identify individual characteristics of the drug action associated with the fact that the drug action is genetically determined. The basis of genetic features that determine individual sensitivity to it are single nucleotide polymorphisms (SNPs): CYP2C9, VKORC1, and CYP4F2.

Antithrombotic therapy is a necessary component of pharmacotherapy for acute coronary syndrome (ACS) and is performed according to clinical guidelines. For patients with ACS, the first step in seeking medical care is to prescribe loading doses of antiplatelet agents and intravenous heparin. The authors aimed to evaluate the real practice of prescribing antithrombotic therapy to patients with ACS in emergency medical care with determining options for individual drug selection.

Phagocytic activity of leukocytes (PAL) is a laboratory indicator that represents the percentage of neutrophils and monocytes capable of binding to pathogenic microflora and digesting it. PAL reflects the body’s ability to effectively fight bacterial infection. This indicator is expected to increase against the background of acute infectious diseases. With a decrease in immunity due to chronic diseases, PAL decreases. The authors’ goal was to study the feasibility of using PAL of whole blood in patients with community-acquired pneumonia in pediatric practice.

Nowadays, many antibiotics no longer help, and how to treat patients remains unclear. Antibiotic resistance is a global health problem in the modern world. One of the reasons for this is the low level of knowledge of doctors in the field of antimicrobial therapy and, accordingly, incorrect treatment. The aim of the study was to determine the level of knowledge of antimicrobial therapy among general practitioners using an anonymous survey method and compare the results obtained depending on GPs’ work experience.

The development of thrombotic complications against the background of COVID-19 is a serious problem that requires the prescription of adequate anticoagulant therapy. The authors analyzed the quality of domestic CGs on the use of DOACs for the prevention of thrombotic complications in COVID-19 patients using the RIGHT tool.

The authors set the goal of conducting an ultrastructural analysis of the effect of pegylated hyaluronidase on human hepatocyte cell culture from the standpoint of assessing toxicity and safety of use.

The rise of antimicrobial resistance is an ongoing global health issue as the most commonly used antibiotics become less effective in treating and preventing infectious diseases. In surgical hospitals, antibiotic prophylaxis has become a routine standard for the prevention of surgical site infections (SSIs), one of the most common types of hospital-acquired infections. The authors’ goal is to evaluate the rationality of antibiotic prophylaxis and monitor the state of antibiotic resistance in surgical departments in hospitals in the city of Voronezh.

The authors set out to evaluate the clinical course, risk of development and prognosis of comorbid conditions according to the Carlson Index in patients with coronary heart disease, as well as to determine the relationship between chronic obstructive pulmonary bronchitis.

The authors set the goal to study the features of clinical and laboratory parameters in patients with coronary heart disease and chronic obstructive pulmonary bronchitis with comorbid conditions.

Representatives of the gut microbiota perform a number of important functions in the human body: they provide colonization resistance, stimulate the development of the immune system, participate in the synthesis of vitamins and other biologically active substances (for example, short-chain fatty acids), etc. The aim of the study is to substantiate the possibility of using commercial nutrient media to isolate obligate anaerobic representatives of the intestinal microbiota.